Gut - InMd 6409

Pathophysiology Segment Coordinator

Ron Soltis, MD
A-538 Mayo
612-625-5680
solti001@umn.edu

Course Objectives

The overall objective of the Gut segment is to present the pathophysiology of hepatic and gastrointestinal disease. Within this context several general objectives can be listed (specific objectives are presented at the beginning of each chapter or lecture).

By the end of the Gut segment, the student should be able to:

  1. List and define the five major functions of the normal liver and explain how each is altered with liver disease.
  2. List and explain the pathophysiology, laboratory abnormalities and clinical manifestations of the following:
    1. acute hepatocellular injury
    2. chronic hepatocellular injury
    3. acute cholestatic liver injury
    4. chronic cholestatic liver injury
  3. Explain the pathophysiology and clinical manifestations of the following specific liver diseases:
    1. viral hepatitis (A, B, C, D, and E)
    2. alcohol-induced liver disease
    3. drug hepatitis
  4. Explain the normal and abnormal metabolism of bile salts and bilirubin.
  5. Explain the pathophysiology of each of the following clinical manifestations of liver disease:
    1. portal hypertension
    2. ascites
    3. hepatic encephalopathy
    4. altered hormonal balance
    5. altered drug metabolism
    6. functional renal failure
  6. Explain the pathophysiology of esophageal dysmotility, reflux esophagitis, achalasia, esophageal spasm, and scleroderma related esophageal changes.
  7. Explain normal gastric physiology with regards to acid secretion and motility.
  8. Explain the pathophysiology of peptic ulcer disease and gastritis.
  9. Discuss the mechanism of normal digestion, absorption, and motility.
  10. Explain the pathophysiology of acute and chronic pancreatitis.
  11. Explain the etiology, pathophysiology and clinical manifestations of maldigestion and malabsorption.
  12. List and explain the pathophysiology of the 4 major mechanisms of diarrhea.
  13. Explain the pathophysiology of diverticulosis, irritable bowel syndrome and constipation.
  14. Explain the etiology of excess flatus.
  15. Discuss the 3 major types of abdominal pain, their etiologies and the approach to determining their causes.
  16. Discuss the pathophysiology of intestinal obstruction and appendicitis.

Sample Schedule from previous year

 

NOTE: This page includes only general information for this course. For actual course website, students and faculty should log-on to the myU Portal